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. 2011 Mar 7;121(4):1657–1666. doi: 10.1172/JCI45538

Figure 2. Adaptive immunity is not required for the initiation of colitis in IEC C1galt1–/– mice.

Figure 2

(A) Representative H&E-stained colonic sections indicate similar colonic inflammation in IEC C1galt1–/– mice with and without Rag1 deficiency at 2 weeks. (B) Clinical DAI (mean ± SD, n = 10 mice/group) of IEC C1galt1–/– mice based on diarrhea, fecal occult blood, and rectal prolapse. *P < 0.05. (C) Cryosections of IEC C1galt1–/–Rag1–/– colon stained with mAbs to myeloid cells (Gr1) and TNF at 3 weeks. Arrows mark infiltrates in epithelium. Inset (original magnification, ×400) highlights TNF-positive myeloid cells. Scale bars: 100 μm in A, 50 μm in C. Data are representative of at least 3 experiments.