Table 2.
Kinase Activation in Response to CXCL5 in HUVECs
| Phospho-Kinase | % increase | P value |
|---|---|---|
| Akt (S473) | 24.7 | 0.06 |
| Akt (T308) | 25.82 | 0.1 |
| TOR | 74.9 | 0.01 |
| GSK (3α/β) | 20.5 | 0.07 |
| p70 S6 kinase (T389) | 37.1 | 0.1 |
| p70 S6 kinase (T229) | 51.7 | 0.03 |
| p70 S6 kinase | 31.1 | 0.05 |
| ERK1/2 | 44.3 | 0.007 |
| MEK1/2 | 34.0 | 0.01 |
| p38α | 16.2 | 0.3 |
| JNK pan | 21.3 | 0.001 |
| RSK 1/2 | 36.5 | 0.002 |
| RSK 1/2/3 | 28.9 | 0.03 |
| FAK | 47.8 | 0.08 |
| β-catenin | 20.5 | 0.003 |
| Paxillin | 27.5 | 0.1 |
| Pyk-2 | 31.0 | 0.01 |
| Src | 59.4 | 0.002 |
| Fyn | 38.0 | 0.01 |
| Lyn | 43.8 | 0.05 |
| Yes | 35.1 | 0.02 |
| Lck | 39.7 | 0.001 |
| Hck | 38.2 | 0.02 |
| JNK pan | 21.3 | 0.1 |
| STAT1 | 60.1 | 0.007 |
| STAT2 | 36.3 | 0.01 |
| STAT3 | 43.5 | 0.0001 |
| STAT4 | 51.1 | 0.007 |
| STAT5a | 30.5 | 0.001 |
| STAT5a/b | 61.3 | 0.01 |
| STAT5b | 43.8 | 0.005 |
| STAT6 | 46.4 | 0.01 |
| p53 (S15) | 14.0 | 0.004 |
| p53 (S392) | 10.1 | 0.01 |
| p53 (S46) | 10.8 | 0.003 |
| p27 (T157) | 29.7 | 0.01 |
| P27 (T198) | 33.5 | 0.02 |
| CHK2 | 40.3 | 0.005 |
| C-Jun | 6.3 | 0.03 |
| CREB | 34.0 | 0.006 |
| eNOS | 3.06 | 0.09 |
| HSP27 | 36.4 | 0.03 |
| AMPKα1 | 22.7 | 0.01 |
| AMPKα2 | 31.4 | 0.08 |
| MSK1/2 | 24.1 | 0.01 |
| PLCg-1 | 29.9 | 0.03 |
Cell lysate from CXCL5-treated (0.5 ng/ml) HUVECs were used for phospho-kinase array.