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. 2011 Jan;178(1):245–252. doi: 10.1016/j.ajpath.2010.11.040

Figure 5.

Figure 5

RhoB loss improves wound healing in hyperglycemic mice. A: There was no difference in the wound-healing rates of the non–STZ-treated RhoB+/+ and RhoB−/− animals. When the same experiment was performed in STZ-treated RhoB−/− and RhoB+/+ hyperglycemic mice, the RhoB+/+ animals showed significantly delayed wound healing compared with the non–STZ-treated controls and the hyperglycemic RhoB−/− mice (triangles, solid line). STZ treated RhoB−/− mice healed significantly faster than their wild-type peers. Values are the mean ± SE. The SE is shown as the error bar. RhoB+/+, n = 18; RhoB−/−, n = 20; STZ-RhoB+/+, n = 33; and STZ-RhoB−/−, n = 20. *P < 0.05 versus diabetic RhoB−/−. B: Histological examination of the wounds at day 14. No difference was observed in the wounds of RhoB−/− and RhoB+/+ untreated mice. On the other hand, the STZ-treated RhoB+/+ mice showed a significant delay in their wound-healing process when compared with the STZ-treated RhoB−/− mice. The STZ-treated RhoB+/+ unhealed wounds showed extended granulated tissue, edema, significant scabbing, and lack of a good layer definition. On the other hand, the wounds of hyperglycemic RhoB−/− mice showed histological features similar to those of the untreated mice. C: Representative image of the wound-healing process showing the delayed wound healing in RhoB+/+ hyperglycemic animals.