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. 2011 Feb;178(2):803–816. doi: 10.1016/j.ajpath.2010.10.034

Figure 3.

Figure 3

Tau immunohistochemical labeling of tissue sections of the hippocampus of 9-month-old wild-type, tau−/−, Tg30, and Tg30xtau−/− mice. A–D: The B19 tau antibody (reacting with mouse and human tau) shows the somatodendritic accumulation of tau in the CA1 sector of Tg30 and Tg30xtau−/− mouse hippocampus. E–H: The BR21 antibody specific for human tau also shows the somatodendritic accumulation of tau in Tg30 and in Tg30xtau−/− mice and does not show any immunoreactivity in wild-type mice. Some neurons containing neurofibrillary tangles show a stronger labeling in the CA1 sector of Tg30 and Tg30xtau−/− mouse hippocampus. I–L: The mTau-5 antibody specific for murine tau shows an abnormal somatodendritic accumulation of murine tau (arrows) in the subiculum of Tg30 mice, but not in the other genotypes. Blood vessels show a nonspecific labeling due to the use of an anti-mouse secondary antibody. Scale bar = 20 μm (A–L).