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. 2011 Feb;178(2):803–816. doi: 10.1016/j.ajpath.2010.10.034

Figure 6.

Figure 6

The load of neurofibrillary tangles estimated with Gallyas staining was increased in Tg30xtau−/− mice, compared with Tg30 mice (12-month-old mice). A–C: Hippocampus (CA1 sector). The density of NFTs was significantly higher in Tg30xtau−/− than in Tg30 mice (C). *P <0.05 by unpaired t-test (P = 0.032) (Tg30, n = 5; Tg30xtau−/−, n = 6). D–F: Lumbar spinal cord, anterior horn. The density of NFTs was not significantly different between Tg30xtau−/− andTg30 mice (F) (P = 0.8670). The density of NFTs is expressed as the number of NFTs per slice counted in the hippocampus and subiculum in three adjacent sagittal sections (Tg30, n = 6; Tg30xtau−/−, n = 8).