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. 2011 Jan;178(1):161–174. doi: 10.1016/j.ajpath.2010.11.001

Figure 1.

Figure 1

Hepatic injury in NOD/SCID mice. Vehicle-treated control mice and mice treated with Rif and Phen for 3 days, followed by either 125- or 150-mg/kg MCT, are shown. A: Serum ALT levels. B: Serum bilirubin levels. C: Grade of encephalopathy. D: Survival curves in animals. E through H: Normal liver histological features in a vehicle-treated control mouse (E), whereas mice 1 day (F), 4 days (G), and 7 days (H) after Rif, Phen, and 125-mg/kg MCT showed loss of liver parenchyma (pink areas without blue nuclei). Original magnification, ×100. Scale bar = 100 μm (hematoxylin-eosin stain).