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. 2011 Jan;178(1):161–174. doi: 10.1016/j.ajpath.2010.11.001

Figure 2.

Figure 2

Hepatic apoptosis and proliferation after drug-induced damage in NOD/SCID mice. The terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assays (A, C, E, and G) and Ki-67 immunostaining (B, D, F, and H) are shown. A and B: Normal liver with absence of TUNEL or Ki-67 expression. C: The DNase-treated liver as a positive control for TUNEL. D: Mouse liver 40 hours after partial hepatectomy showing widespread Ki-67 expression in hepatocytes. E and F: Infrequent TUNEL-positive cells (E) and hepatocytes with Ki-67 (F) 3 days after Rif, Phen, and 125-mg/kg MCT. G: Infrequent TUNEL-positive cells 7 days after Rif, Phen, and MCT. H: Ki-67 expression in periportal hepatocytes 8 days after Rif, Phen, and MCT. Original magnification, ×200. Scale bar = 100 μm (left, methylgreen counterstain; right, toluidine blue counterstain).