Figure 7.

Outcomes in animals with ALF after cell therapy. A: Survival curves in mice with ALF after sham treatment with microcarriers alone and reversal of mortality after i.p. transplantation of 1 × 10⁶ F344 rat hepatocytes (*P < 0.01, log-rank test). B: Encephalopathy in sham-treated mice and its absence in mice treated by transplantation of F344 rat hepatocytes. C: Decreases in serum bilirubin levels in treated mice. D: Improvements in prothrombin times after cell therapy. All data were from three to five mice per time point. *P < 0.01. E: Healthy transplanted hepatocytes and microcarriers (mc) in conglomerates recovered after 14 days from the peritoneal cavity (hematoxylin stain). F: Histochemical staining showing glycogen in transplanted hepatocytes (pink) adjacent to mc in the peritoneal cavity. Original magnification, ×200. Scale bar = 100 μm.