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. 2011 Mar;178(3):1350–1360. doi: 10.1016/j.ajpath.2010.11.061

Figure 3.

Figure 3

The p63-null mice generate a single-layered urothelium displaying an umbrella cell phenotype. A: Immunofluorescence analysis of a representative urothelium from a wild-type p63 mouse showing that p63 is expressed in the basal and intermediate layers, whereas umbrella cells display a p63-negative phenotype. CK18 expression shows an inverse phenotype, which is detected only in umbrella cells. B: Immunofluorescence analysis of UPII (two upper panels) and CK5 (two lower panels) in representative wild-type and p63-null mice. p63-null urothelium is composed of cells displaying a UPII-positive phenotype and lacking expression of CK5, consistent with an umbrella cell phenotype. Scale bar = 100 μm.