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. 2011 Mar;178(3):1350–1360. doi: 10.1016/j.ajpath.2010.11.061

Figure 7.

Figure 7

Schematic representation of a proposed novel categorization of invasive bladder carcinomas. It is our theory, based on ΔNp63 and CK expression, that bladder cancer could be categorized into two subtypes: (1) basal-like phenotype displaying ΔNp63 and high molecular weight CKs (CK5 and CK10), but lacking low molecular weight CKs, such as CK20 and (2) luminal-like phenotype displaying CK20 but lacking ΔNp63 and CK5. Basal-like invasive bladder carcinomas were found in this study to be associated with a poor clinical outcome when compared with luminal-like tumors.