Figure 5.

In vivo effects of rapamycin: combination of antiproliferative and antiangiogenic mechanisms. A: Morphometric analyses of intrahepatic lesions: the mitotic index and the proliferative index (Ki-67 immunoreactive cells) were significantly decreased on rapamycin treatment (*P < 0.05), whereas the apoptotic index was not modified. B: Representative immunostainings for VEGF and CD31 (arrows) in tumor nodules (original magnification, ×10). C: Morphometric analysis showing the decrease of intratumoral microvascular density on rapamycin treatment (*P < 0.05).