Figure 1.

Effects of sActRIIB therapy on body weight, lean muscle, skeletal muscle, and adipose tissue mass. A: Growth curves were plotted to show the changes in body weight of control mdx mice and mdx mice treated with 1.0 mg/kg⁻¹ or 10.0 mg/kg⁻¹ sActRIIB. B: Body weight at the termination of the trial was significantly greater for mdx mice treated with the higher dose, but not the lower dose, compared with control mdx mice. C: Lean muscle mass but not adipose tissue mass (nuclear magnetic resonance quantification) was significantly greater in mdx mice treated with 10.0 mg/kg⁻¹ sActRIIB, compared with control mdx mice. D: Gross anatomical examination revealed increases in skeletal muscle mass in mdx mice treated with the 10.0 mg/kg⁻¹ dose of sActRIIB, compared with control mdx mice. ***P < 0.0001.