Figure 4.
Effects of sActRIIB therapy on ex vivo contraction force of the EDL muscle. A: Representative twitch force traces from EDL muscles of control mdx mice and mdx mice treated with 1.0 mg/kg−1 or 10.0 mg/kg−1 sActRIIB. B: At both doses, absolute twitch force was significantly greater in mice treated with sActRIIB. C: Normalized twitch force was greater in EDL muscle only at the lower dose. D: Representative tetanic force traces from EDL muscles of control mdx mice and mdx mice treated with 1.0 mg/kg−1 or 10.0 mg/kg−1 sActRIIB. E: At both doses, absolute twitch force was significantly greater in mice treated with sActRIIB. F: Normalized tetanic force was greater in EDL muscles only at the lower dose. The dashed line (B, C, E, and F) indicates values for untreated, age-matched, wild-type BL/10 mice. *P < 0.05; **P < 0.001; ***P < 0.0001.