Figure 6.

Effects of sActRIIB therapy on histopathology and hydroxyproline content of diaphragm and tibialis anterior muscle. Limited effects on diaphragm and tibialis anterior histopathology were observed in mdx mice treated with 1.0 mg/kg⁻¹ or 10.0 mg/kg⁻¹ sActRIIB, compared with mdx control mice. Representative diaphragm sections, H&E stain (A and B) and Mason's trichrome stain (C). Representative tibialis anterior sections H&E stain (D and E). No significant difference was observed in the hydroxyproline content of the diaphragm (F) and the tibialis anterior muscle (G). Original magnification, 10× (A and D); 40× (B, C, and E). Scale bars = 100 μm (all images).