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. 2011 Mar;178(3):1361–1373. doi: 10.1016/j.ajpath.2010.11.074

Figure 2.

Figure 2

COX-2 expression in hepatocytes did not mediate the development of liver fibrosis. Survival curves (A) and the loss of body weight (B) of WT (n = 14) and Tg (n = 14) mice after the MCD diet. C: H&E and Masson's trichrome staining of liver sections of WT and Tg mice after the MCD diet and sacrificed at 15 weeks. Micrographs were taken with a Color View Camera in a Vanox Olympus microscope at 20× magnification. Scale bar = 100 μm (for all images). D and E: α-SMA, MMP-9, COX-2 protein expression measured by Western blot (D) and hydroxyproline levels analyzed by ELISA (E) in WT and Tg liver after the MCD diet. Data are reported as means ± SD of six animals per condition.