Table 2.
Morphometric Analysis and Incidence of Pathological Signs in Livers of WT and COX-2 Tg Male Mice after DEN Treatment
| Treatment | Sample size | Tumors, ≥0.5 mm (no.) | Tumor area (%) | Maximal size (mm) | Preneoplastic lesions, no. (%) | Adenomas, no. (%) | Hepatocellular carcinomas, no. (%) | Lung metastasis, no. (%) |
|---|---|---|---|---|---|---|---|---|
| WT | ||||||||
| DEN10 | 12 | 0 | 0 | 0 | 1 (8) | 0 (0) | 0 (0) | 0 (0) |
| DEN25 | 12 | 42.5 ± 9.4 | 8.0 ± 2.6 | 6.8 ± 1.5 | 1 (8) | 11 (92) | 0 (0) | 0 (0) |
| DEN40 | 12 | 38.7 ± 0.5 | 43.7 ± 3.9 | 19.3 ± 2.4 | 0 (0) | 0 (0) | 12 (100) | 3 (25) |
| Tg | ||||||||
| DEN10 | 12 | 0 | 0 | 0 | 3 (25) | 0 (0) | 0 (0) | 0 (0) |
| DEN25 | 12 | 59.2 ± 11.8 | 8.8 ± 2.38 | 5.5 ± 1.1 | 0 (0) | 12 (100) | 0 (0) | 0 (0) |
| DEN40 | 12 | 43.0 ± 6.3 | 43.5 ± 6.0 | 14.7 ± 0.7 | 0 (0) | 0 (0) | 12 (100) | 8 (67)⁎ |
⁎
P < 0.05 vs. WT.