Table 3.

Heat Map Data for Gene Expression

Layout	1	2	3	4	5	6	7	8	9	10	11	12
A	Akt1	Akt2	Angpt1	Apaf1	Atm	Bad	Bax	Bcl2	Bcl2l1	Birc5	Brca1	Casp8
	−1.16	−1.42	−1.01	1.02	−1.09	1.17	−1.08	1.14	1.20	1.27	1.12	1.32
B	Ccnd1	Ccne1	Cdc25a	Cdh1	Cdk2	Cdk4	Cdkn1a	Cdkn2a	Cflar	Chek2	Col18a1	Ctnnb1
	1.00	4.19	1.15	1.03	−1.68	1.38	1.75	1.36	1.23	2.8	1.28	−1.27
C	E2f1	Egfr	Ets2	Fas	Fgf1	Fgfr2	Figf	Fos	Grb2	Hgf	Ifnb1	Igf1
	1.35	−1.13	−1.01	1.22	−1.26	−1.31	−1.29	−1.64	1.09	1.10	−1.20	−1.50
D	Itga2	Itga3	Itga4	Itgav	Itgb1	Itgb3	Jun	Kiss1	Map2k1	Mcam	Mdm2	Met
	1.27	1.10	1.43	1.20	−1.08	1.05	−1.61	−1.28	1.08	1.29	−1.12	−1.22
E	Mmp2	Mmp9	Mta1	Mta2	Muc1	Myc	Ncam1	Nfkb1	Nfkbia	Nme4	Pdgfa	Pdgfb
	1.52	−1.15	−1.18	1.15	−1.37	2.78	−1.04	1.07	−1.17	−1.31	−1.04	1.09
F	Pik3r1	Plau	Plaur	Pten	Raf1	Rb1	S100a4	Serpinb2	Serpine1	Syk	Tek	Tert
	1.30	1.52	1.38	−1.07	−1.17	1.03	1.30	−1.20	−1.19	1.42	1.12	−1.66
G	Tgfb1	Tgfbr1	Thbs1	Timp1	Tnf	Tnfrsf10b	Tnfrsf1a	Trp53	Twist1	Vegfa	Vegfb	Vegfc
	1.38	−1.06	2.37	−1.20	−1.45	2.07	1.05	−1.03	−1.03	1.03	1.48	1.36

Gene expression between Tg and WT mice at 25 weeks after DEN treatment was compared using RT² Profiler version 3.2, a Web-based software package for the Profiler PCR array system (SABiosciences-Qiagen, Frederick, MD; http://www.sabiosciences.com/pcr/arrayanalysis.php); this software automatically performs all ΔΔC_T-based fold-change calculations from the specific uploaded raw threshold cycle data.