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. 2011 Mar;178(3):989–996. doi: 10.1016/j.ajpath.2010.12.003

Figure 2.

Figure 2

Profile of epithelial markers in circulating tumor microemboli (CTM) and circulating tumor cells (CTCs) from lung cancer patients. Blood samples from lung cancer patients were subjected to ISET filtration and CTM/CTCs were profiled for E-cadherin or CKs (see Materials and Methods). A: E-cadherin expression profiles in CTM (left panel), CTCs (middle panels) from patients with SCLC, and in cultured SCLC H526 cells that served as positive control for normal staining profile of E-cadherin. Black and white arrows indicate nuclear staining of E-cadherin and loss of E-cadherin, respectively. B: The heterogeneous expression of CKs in CTM (left and middle left panel) and CTCs (middle right and right panel) from patients with lung cancer. Images shown are representative from the patient cohort (see Table 1).