eNOS overexpression increases the paracrine potential of BMMNCs. A: Quantification by enzyme-linked immunosorbent assays of secretion of VEGF-A in cell culture medium. Values are mean ± SEM; n = 4. **P < 0.01 versus WT BMMNCs, ‡P < 0.05 versus WT diabetic BMMNC, and †P < 0.01 versus ApoE KO BMMNCs. ND indicates not detected. B: Quantitative evaluation of ischemic femoral artery diameter isolated from control mice after intraluminal injection of BMMNCs isolated from WT, eNOS transgenic control, diabetic, or ApoE KO mice. Values are mean ± SEM; n = 10. *P < 0.05 versus WT, ‡P < 0.05 versus WT diabetic BMMNCs, and †P < 0.05 versus ApoE KO BMMNCs.