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. 2011 Feb;178(2):515–524. doi: 10.1016/j.ajpath.2010.10.010

Figure 5.

Figure 5

Comparative analysis of the methylation value using the 77 cancer and corresponding normal tissue samples. P values calculated with the Mann-Whitney test. IM, intestinal metaplasia. A: Methylation values were more variable in cancer tissues than in normal mucosa. B: Methylation value of CA9 was significantly lower in the case with high CA IX expression compared with those with low CA IX expression (P = 0.003). C: Diffuse-type gastric cancer (n = 47) is highly methylated compared with intestinal-type cancer (n = 30) (P = 0.003). D: Methylation value of intestinal-type cancer is significantly lower than in normal tissue (P = 0.027). E: Methylation value of diffuse-type cancer is significantly higher than in normal tissue (P = 0.042). F: Presence of intestinal metaplasia had no effect on methylation value in normal mucosa (P = 0.308).