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. 2011 Jan;178(1):98–109. doi: 10.1016/j.ajpath.2010.11.025

Figure 1.

Figure 1

Chronic hypoxia exposure interferes with total body weight gain in MKP-1-deficient mice. A: Genotyping of MKP-1+/+, MKP-1+/−, and MKP-1−/− mice by PCR. Mouse tail DNA amplified by PCR shows a MKP-1 band of 300 bp and a neomycin band of 580 bp. B: Weight gain in mice in the absence of MKP-1 expression is attenuated by hypoxia exposure (n = 8 to 15 animals/group). MKP-1−/− mice had marked decrease in gain of body weight compared with MKP-1+/+ and MKP-1+/− mice after 6 weeks exposure to a simulated altitude of ∼5182 m (∼17,000 feet). *P < 0.05 compared with SL group of MKP-1-deficient mice. SL, sea level; DA, Denver altitude; HYP, high-altitude hypoxia.