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Deletion of MKP-1 affects the expression of αSMA and VEGF in the lung. A: αSMA expression is up-regulated in hypoxia-exposed MKP-1-deficient lung (n = 3 to 4 animals/group). Insets identify areas from MKP-1−/− lung of SL and HYP groups that are magnified in the row below, with red arrows indicating the vessels positive for αSMA staining. B: VEGF expression is increased in hypoxic lung of wild-type mice (n = 3 to 4 animals/group). Original magnification ×400; ×1600 (insets).
