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. 2011 Jan;178(1):98–109. doi: 10.1016/j.ajpath.2010.11.025

Figure 4.

Figure 4

Hypoxia induces loss and structural remodeling of αSMA-positive vessels (<50 μm OD) in MKP-1-deficient lung. A: αSMA-positive vessel densities are markedly decreased in hypoxic lung of MKP-1+/− and MKP-1−/− mice. Data reported as mean ± SEM, 3 to 5 animals per group. *P < 0.001 compared with SL-exposed MKP-1+/+ lung. **P < 0.001 compared with SL-exposed MKP-1+/− lung. ***P < 0.01 compared with SL- and DA-exposed MKP-1+/− mice and HYP-exposed MKP-1+/+ mice. †P < 0.001 compared with SL-exposed MKP-1−/− mice. ††P < 0.05 compared with SL- and DA-exposed MKP-1−/− mice and HYP-exposed MKP-1+/+ mice. n = 3 to 5 animals/group; 5 to 12 vessels in each lung/animal were counted. B: Hypoxia induces structural remodeling of the vascular wall (wall width to vessel width ratio) in lung of MKP-1+/− and MKP-1−/− mice. *P < 0.001 compared with SL- and DA-exposed MKP-1+/− and HYP-exposed MKP-1+/+ mice. **P < 0.001 compared with SL- and DA-exposed MKP-1−/− and HYP-exposed MKP-1+/+ mice. n = 3 to 5 animals/group; at least 50 vessels/animal were analyzed.