Ki-67-positive cells are most abundant in hypoxic lung of MKP-1+/+ mice. Representative images of lung from MKP-1+/+, MKP-1+/−, and MKP-1−/− mice exposed to SL, DA, and HYP for 6 weeks (n = 3 animals/group). In the MKP-1+/− lung section of HYP group, the small box marks an example of Ki-67-positive nuclei, magnified in the inset; the red arrow points to a Ki-67-positive nucleus. Original magnification ×400; ×1200 (inset).