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. 2011 Mar;178(3):1309–1315. doi: 10.1016/j.ajpath.2010.11.069

Figure 4.

Figure 4

T2-reactive truncated PrPC fragments in non-CJD control brains. A: The cerebral cortices from age-matched control subjects (N1 to N4) were examined by conventional Western blot analysis using the 3F4 antibody without PK treatment. After deglycosylation with PNGase F, major PrPC fragments migrated at 25 kDa. In addition, various truncated PrPC fragments (arrowheads) were also observed. B: T2-reactive truncated PrPC fragments (97-PrPC) could be detected in all control brains. The 97-PrPC fragments migrated at 19 kDa after the deglycosylation. C and D: The 97-PrPC fragments could be detected also in the cerebellums from the control subjects (N1 CE and N2 CE).