Figure 4.

Physiological consequence of Ca²⁺-CaM binding to CaT-L. Normalized (I/I_max) current traces in response to a voltage step to −100 mV for wild-type (A), CaM binding site deletion construct S (B), point mutant construct 6 R/E (C), and disabled phosphorylation site mutant T/A (D). Note the different inactivation profiles. (E) Quantification of the residual current fraction within the first 20 ms (r20) and within the next 930 ms (r930). In the case of barium as charge carrier, residual current fraction (r930) was calculated from peak to t = 930. (F) Model of CaT-L regulation by PKC and Ca²⁺-CaM.