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Summary of a putative pathway that regulates FGF-2–mediated wound repair through the TGF-β/Smad signaling pathway. The TGF-β promotes the phosphorylation of Smad2/3, resulting in VIC wound repair. Betaglycan binds endogenous TGF-β, resulting in less available TGF-β to bind to its signaling receptors. The FGF-2 also binds betaglycan, which makes more TGF-β available for receptor signaling.
