Table 1.
ERCC1 and RRM1 Expression Categories by Patient Demographics and Disease Characteristics Stratified by Contributing Center
|
P value (adjusted by center) |
||
|---|---|---|
| Characteristics | ERCC1 | RRM1 |
| Sex | ||
| Male | 0.04 | 0.04 |
| Female | (F > M) | (F > M) |
| Age, y | ||
| <55 | ||
| 55–64 | 0.50 | 0.04 |
| >64 | (older > young) | |
| WHO-PS | ||
| 0 | ||
| 1 | 0.79 | 0.06 |
| 2 | (0 > 1 > 2) | |
| Stage | ||
| I | ||
| II | 0.53 | 0.75 |
| III | ||
| Tumor by TNM | ||
| 1 | ||
| 2 | 0.93 | 0.82 |
| 3 and 4 | ||
| Nodes by TNM | ||
| 0 | ||
| 1 | 0.65 | 0.82 |
| 2 | ||
| Histopathologic findings | ||
| Adenocarcinoma | ||
| Squamous cell carcinoma | 0.70 | 0.02 |
| Other | (adenocarcinoma > squamous cell carcinoma) | |
| Pleural invasion | ||
| Absent | 0.68 | 0.46 |
| Present | ||
| Vascular invasion | ||
| Absent | 0.06 | 0.13 |
| Present | (absent > present) | |
| Lymphatic invasion | ||
| Absent | 0.55 | 0.40 |
| Present | ||
| Lymphoid infiltration | ||
| Not intense | 0.66 | 0.38 |
| Intense | ||
| Type of surgery | ||
| Lobe/segmentectomy | 0.72 | 0.18 |
| Pneumonectomy | ||
| Quality of specimen | ||
| Good | 0.007 | 0.78 |
| Average (poor specimens excluded) | (average > good) | |
WHO-PS, World Health Organization Performance Scale; F, female; M, male.