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. 2011 Feb;178(2):662–671. doi: 10.1016/j.ajpath.2010.10.028

Figure 1.

Figure 1

Effects of the lack of serotonin in the gut in the development of DSS-induced colitis. Effects of the lack of serotonin on proinflammatory cytokines [IL-17 (A), IFN-γ (B), and IL-12p40 (C)]. Histamine (D) and PGE2 (E) levels in DSS-induced colitis. TPH1+/+ and TPH1−/− mice were given a 5% DSS solution in the drinking water to induce colitis and were sacrificed on day 5 after DSS. Each value represents mean ± SEM from eight mice. Significantly lower (*P < 0.05) in DSS-treated TPH1−/− mice compared with DSS-treated TPH1+/+ mice. F: IL-12p40 production from DC (2.106 cells/ml) isolated from colitic (TPH1−/−) mice and cultured with medium or with the presence of LPS (100 ng/ml) *P < 0.05 compared with medium. **P < 0.05 compared with TPH1+/+. Data are representative of two independent experiments with quadruplicated cultures using seven mice, mean ± SEM.