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. 2011 Feb;178(2):679–687. doi: 10.1016/j.ajpath.2010.10.021

Figure 2.

Figure 2

Effects of MIF on the production of SCF, ET-1, and PGE2 by keratinocytes. A: Cultured keratinocytes were treated with 100 ng/ml MIF or various doses of UV-B for 24 hours. The concentrations of SCF, ET-1, and PGE2 protein in the culture media were determined by ELISA. The results are expressed as the mean ± SD of five experiments (*P < 0.005 and **P < 0.001). B: Keratinocytes were stimulated with 0, 50, or 100 ng/ml MIF, and the expression of SCF mRNA was evaluated by real-time RT-PCR (n = 5; *P < 0.001, **P < 0.01, and ***P < 0.05 versus 0 ng/ml). The data shown are representative of three independent experiments.