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. 2011 Jan;178(1):261–272. doi: 10.1016/j.ajpath.2010.11.020

Figure 3.

Figure 3

Analysis of the muscle fiber pathology and morphology. GAS and tibialis anterior muscles transduced with AAV6-shFKRP were collected 2 months and 10 months postinjection. A: Cryo-thin sections of the muscle samples were analyzed using H&E staining. Similar pathological signs in the GAS and TA muscles were observed in both AAV-treated and PBS-injected groups at 2 months postinjection. Note that more centrally nucleated myofibers were found in the shFKRP2 + 5–treated muscle at 10 months postinjection (arrows). Scale bar, 100 μm. B: Increase of connective tissue deposition in the shFKRP-treated muscle. Masson trichrome staining was performed on the cryo-thin section of GAS muscles from each treatment group at 10 months postinjection. Note that connective tissues were frequently found in the intermediate of myofibers (arrows) in both single- and dual-cassette shFKRP-treated groups. Scale bar, 100 μm.