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Results of MSH2 hypermethylation test by methylation-specific PCR and fragment length analysis. A: Shows the results of the ABI-based fragment analysis for methylation-specific primers in region 1 of the MSH2 promoter. MSH2 hypermethylation can be seen in tumor and normal tissue in a case with a EPCAM/TACSTD1 deletion. In contrast, the negative control case (loss of MLH1 expression) does not show MSH2 methylation. B: Shows similar data for region 3 of the MSH2 promoter.
