Figure 5. Effect of N-acetyl-cysteine (NAC, 0.5 and 5 mmol/L) intervention on menadione toxicity in each FAO disorder under variable conditions.

Logarithmic transformation followed by paired t-test compares menadione toxicity in each FAOD with and without NAC, under each experimental condition. This figure shows that NAC at both concentrations was significantly effective for SCADD, CPT2/MTPD, MCADD patient fibroblasts under all experimental conditions. In the control fibroblasts, NAC at 5 mmol/L was effective under all experimental conditions.