Figure 2.

The schematic diagram of a prototype design of the AFUS. (a) Targeting the ultrasound foci using lasers to a deep-seated target, where x is the desired depth and w is the distance between two laser beams on the surface. (b) Photograph of the AFUS applicator with lasers shining on an object. The two transducers are shown without capsules. (c) An experimental setup for in vivo ablations in mouse tumors showing the water-filled capsules attached to the transducers to couple the sound waves to the tumor.