Figure 1.

Concentration-dependent suppression of human cardiac Na⁺ currents by EPA. (A) Original current traces of I_Na in the absence (Control) and presence (EPA) of 5 μM EPA were evoked by depolarizing pulses from a holding potential of −150 mV to 30 mV for the wild type and three mutants. The membrane holding potential was −150 mV and the rate of pulses was 0.1 Hz. (B) The amplitude of peak Na⁺ currents shown as in A was calculated in the absence and presence of various concentrations of EPA. The EPA-induced inhibition of I_Na is concentration-dependent. Each data point represents the average value of at least seven individual cells.