Figure 5.

Inhibition of I_Na by other fatty acids. Na⁺ currents were evoked by single-step voltage pulses from a holding potential of −120 to 30 mV. I_Na of the wild type, Y1767K, and F1760K was significantly inhibited by 5 μM docosahexaenoic acid (DHA, C22:6n-3), oleic acid (OA, C18:1n-9), or stearic acid (SA, C18:0). In contrast, I_Na of N406K was not significantly inhibited by the fatty acids. Each bar represents the average value of at least four individual cells. *, P < 0.05; **, P < 0.01; I_Na in the presence of 5 μM fatty acids versus the corresponding control for the wild type or their mutants.