FIG. 2.
The vasodilatation to Angeli's salt is mediated by BKCa and KV channels and soluble guanylyl cyclase. Summary data showing the effect of K-channel blockers (A) and high K+ and ODQ (B) on dilatation to Angeli's salt (AS). AS (30 μM) was added to the bath during the period indicated by the bar (0–360 s). The dilatation under control conditions (n = 13) was significantly reduced in the presence of either iberiotoxin (IbTx, 100 nM, n = 5) or 4-AP (150 μM, n = 5) at the 5 min point. The combination of IbTx and 4-AP almost fully inhibited dilatation to AS (n = 4). This block was matched in the presence of either 45 mM K+ (n = 5) or the sGC inhibitor ODQ (10 μM, n = 5). *p < 0.05 vs control, 5 min.