Table 1.

Parameters measured in the plasma of apoE-null mice exposed to water or acrolein.

	Control	Acrolein
Lipids
Cholesterol (mg/dL)	473 ± 18	564 ± 17^*
Triglycerides (mg/dL)	105 ± 5	118 ± 8
Total Lipoprotein abundance (nmoles/L)
Total VLDL and chylomicron particles	183 ± 5	284 ± 14^*
Total LDL Particles	677 ± 58	924 ± 10^*
Total IDL Particles	378 ± 38	552 ± 27^*
Total HDL Particles	11040 ± 697	11222 ± 2000
VLDL Particle abundance (nmoles/L)
Large VLDL Particles	14 ± 2	20 ± 3
Medium VLDL Particles	84 ± 5	126 ± 6^*
Small VLDL Particles	85 ± 3	138 ± 9^*
LDL Particle abundance (nmoles/L)
Large LDL Particles	296 ± 41	372 ± 25
Medium LDL Particles	N.D.	N.D.
Small LDL Particles	N.D.	N.D.
HDL Particle abundance (nmoles/L)
Large HDL Particles	N.D.	N.D.
Medium HDL Particles	1104 ± 80	1303 ± 227
Small HDL Particles	8732 ± 167	9771 ± 1716
Mean particle size (nm)
VLDL	62.8 ± 1.4	61.5± 1.1
LDL	22.6 ± 0	22 ± 0
HDL	8.2 ± 0.1	8±0
Markers of Endothelial Activation
E-Selectin (ng/ml)	57.0 ± 2.8	81 ± 5.9^*
PAI-1 (ng/ml)	27.4 ± 2.0	35.3 ± 2.9^#
Markers of Inflammation
TNFα (pg/ml)	1.7 ± 0.3	1.25 ± 0.3
IL-6 (pg/ml)	5.8 ± 1.8	6.1 ± 1.2
MCP-1(pg/ml)	19.3 ± 7.5	31.6 ± 6.4
GMCSF(pg/ml)	3.5 ± 0.9	2.4± 0.6
Serum Amyloid A (μg/ml)	11.4 ± 2.2	12.1 ±3
Marker of Oxidative Stress
8-iso Prostaglandin F_2α (pg/ml)	817 ± 123	874 ± 147

Value are mean ± SE.

P<0.05

P<0.01

N.D.- Not determined.