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. 2011 Apr;178(4):1782–1791. doi: 10.1016/j.ajpath.2010.12.037

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© 2011 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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Effect of antiangiogenic treatment on EPCs and CECs. Female 129 SvJ mice underwent endometriosis or sham surgery or no surgery (control subjects) (n = 10 per group). Half of the mice of each group received 15 mg/kg Lodamin (Tx; black columns), an oral, nontoxic form of the angiogenesis inhibitor TNP-470, over 7 days. Control subjects received vehicle (V; white columns). Whole blood was taken at the end of the experiment, stained for (A) CEC markers (CD45⁻, CD31⁺, VEGFR-2⁺, CD133⁻) (*P = 0.02; two-way analysis of variance) and (B) EPC markers (CD45⁻, CD31⁺, VEGFR-2⁺, CD133⁺) (**P < 0.001; two-way analysis of variance) and measured using flow cytometry. C: Endometriosis-like lesions were measured with a caliper using the formula of an ellipse. Mean cross-sectional area of endometriosis-like lesions (n = 6 lesions) of mice treated with vehicle or Lodamin (*P = 0.022; repeated-measures analysis of variance). Values shown are mean ± SEM.