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. 2011 Jan 11;19(4):642–649. doi: 10.1038/mt.2010.293

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Copyright © 2011 The American Society of Gene & Cell Therapy

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Rod-derived electroretinography (ERG) following combined suppression and replacement therapy. The right eyes of P5 P347S mice were subretinally injected with a mixture of 6.0 × 10⁸ vp AAV-S and 1.8 × 10¹⁰ vp AAV-R whereas the left eyes were injected with 6.0 × 10⁸ vp AAV-C. Six (n = 17) or twenty weeks (n = 12) postinjection, mice were dark-adapted overnight and rod-isolated ERG responses recorded from both eyes. (a,b) Overlays of the ERG recordings; green and blue lines represent recordings from combined suppression and replacement therapy (S+R) and control (C)-injected eyes, respectively. (c) Mean ERG b-wave amplitudes (µV). Green and blue columns represent values corresponding to S+R and control injected eyes, respectively. Error bars represent SD values and ***P < 0.001.