Figure 6.

In vivo targeting of HER2/neu positive tumors. (a) Luciferase signals analyzed by in vivo imaging. Six- to 8-week-old CB17 SCID mice were injected with U87MG cells (right flank, yellow arrow) and SK-OV-3 cells (left flank, red arrow). After 11 days, 50 µg p24 of D9.29-LV^luc or 5 µg of VSV-G-LV^luc were injected into the tail vein. Two weeks postinjection, in vivo imaging data were monitored. Luciferase signal intensity is expressed as photons/second/square centimeter/steradian (p/sec/cm²/sr). (b) Immediately after imaging, organs were isolated and homogenized. Luciferase activities were quantified and normalized to protein content. D9.29-LV^luc n = 3; mean ± SD; VSV-G-LV^luc n = 4; mean ± SD.