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. Author manuscript; available in PMC: 2012 Feb 22.
Published in final edited form as: Biochemistry. 2011 Jan 31;50(7):1128–1134. doi: 10.1021/bi200002a

Figure 2.

Figure 2

Plasmodium falciparum PNP's active site with bound hypoxanthine (the free base, in cyan), ribose (cyan), and arsenate (purple) (PDP code: 3ENZ). The arsenate position corresponds to the nucleophilic attack by one of the oxygens (marked as O*) on the CI of ribose (O*-C1 distance is 2.3 Å). The arsenate ion is bound via hydrogen bonds (dashed lines) to three arginine side chains (Arg 88, Arg 27, and Arg 45' of the neighboring subunit). Other hydrogen donors to the bound arsenate include the hydroxyl group of Ser 91, and its backbone amide nitrogen.