. Author manuscript; available in PMC: 2012 Apr 1.

Published in final edited form as: Pediatr Clin North Am. 2011 Apr;58(2):407–426. doi: 10.1016/j.pcl.2011.02.005

Table 2.

Cut-off values based on 95% positive predicted values (PPV) for cow’s milk (CM)-specific IgE and skin prick test (SPT) in children with cow’s milk allergy (CMA).

	Age	95% PPV	Methods
CM-specific IgE
Sampson 2001[122]		15 kU_A/L	CAP System FEIA^#
Garcia-Ara et al 2001[123]	<1 year	5 kU_A/L	CAP System FEIA^#
Van der Gugten et al 2008[125]	< 2.5 years	7.5 kU_A/L	CAP System FEIA^#
SPT
Hill et al 2004[124]	< 2 years All children	100% PPV: 6 mm wheal 100% PPV: 8 mm wheal	CM allergen extract
Verstege et al 2005[126]		12.5 mm wheal or 2.7 SI^*	Fresh CM
Calvani et al 2007[127]		15 mm wheal	Fresh CM

SI, ratio of allergen-induced wheal diameter to histamine-induced wheal diameter

Phadia, Uppsala, Sweden