FIG. 6.

Inhibition of compound action potentials (CAPs) of myelinated fibers following concussive brain trauma. (A) Representative traces of evoked CAPs in sham- and brain-injured mice at 24 h post-injury. Evoked CAPs of (B) myelinated (N1) and (C) unmyelinated (N2) axons in the corpus callosum were measured as described in the methods section. Repeated-measures analysis of variance of CAP amplitude revealed an injury effect for the myelinated (p<0.001), but not the unmyelinated, component. Refractoriness for the (D) myelinated and (E) unmyelinated fibers at 24 h and 14 days post-injury (*p<0.04). All values are presented as mean±standard deviation.