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. 2011 Apr;28(4):649–660. doi: 10.1089/neu.2010.1662

FIG. 7.

FIG. 7.

(A and B) Quantitative evaluation of oxidative protein damage by detection of the carbonyl groups introduced into proteins. The levels of the carbonyl groups in the striatum significantly increased 24 h after bilateral common carotid artery occlusion (BCCAO) compared with sham animals (n=6; *p<0.05). (C and D) Representative photomicrographs of 8-oxoG staining. Expression of 8-oxoG increased in the striatum 24 h after BCCAO. 8-oxoG staining co-localized with DARPP-32 staining; however, it did not co-localize with ChAT staining (magnification×400; scale bar=50 μm;. I and Isc, ischemia; 8-oxoG, anti-8-oxoguanine; DARPP-32, anti-dopamine and cyclic AMP-regulated phosphoprotein of relative molecular weight 32,000; ChAT, anti-choline acetyltransferase). Color image is available online at www.liebertpub.com/neu.