Table 2.
Associations of LDL Cholesterol and LDL Particle Number with Incident CVD in Participants with Concordant or Discordant Levels
| Model 1 | Model 2 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean Levels (SD) | LDL-C | LDL-P | LDL-C | LDL-P | ||||||||
| Subgroup | n | CVD Events |
LDL-C | LDL-P | HR (95% CI) |
p | HR (95% CI) |
p | HR (95% CI) |
p | HR (95% CI) |
p |
| Overall | 5598 | 319 | 117 (31) |
1249 (333) |
1.20 (1.08, 1.34) |
0.0009 | 1.32 (1.19, 1.47) |
<0.0001 | 1.28 (1.15, 1.43) |
<0.0001 | 1.35 (1.21, 1.50) |
<0.0001 |
| Concordant | 2775 | 160 | 117 (37) |
1252 (395) |
1.27 (1.12, 1.44) |
0.0003 | 1.27 (1.12, 1.44) |
0.0002 | 1.32 (1.16, 1.50) |
<0.0001 | 1.30 (1.14, 1.48) |
<0.0001 |
| Discordant* | 2823 | 159 | 117 (25) |
1246 (259) |
1.07 (0.88, 1.30) |
0.52 | 1.45 (1.19, 1.78) |
0.0003 | 1.17 (0.96, 1.42) |
0.13 | 1.41 (1.15, 1.75) |
0.001 |
Estimates reported are from multivariable Cox regression analyses. Model 1 was adjusted for age, gender and race. Model 2 was adjusted additionally for systolic blood pressure, hypertension treatment, smoking, body mass index, and diabetes status. Hazards ratios (95% confidence intervals) are for a 1-SD increment of LDL-P or LDL-C, using the SD values in the overall population of 333 nmol/L and 31.4 mg/dL, respectively.
*
This subgroup comprises the combined LDL-P > LDL-C and LDL-P < LDL-C discordant subgroups in Table 1.
Abbreviations: LDL-C, LDL cholesterol; LDL-P, LDL particle number.