Figure 6.

Estimated R₂^* values from single T₂^* correction method (a) and the dual T₂^* correction method (b, c) at increasing SPIO concentrations and different fat-fractions. Error bars show the standard error of the mean. With the single T₂^* correction method, the estimated values of R₂^* increase as SPIO concentrations increase, and there is a strong dependence of the estimated R₂^* with fat-fraction. Using the dual T₂^* correction method, the R₂^* of water is more strongly affected by increasing concentrations of SPIO. Interestingly, there is relatively minimal dependence of the estimated R₂^* values on fat-fraction using the dual T₂^* method. These findings suggest that the dual T₂^* method more accurately reflects the signal behavior of the fat/water/SPIO phantom.