TABLE 2.

Susceptibility of recombinant viruses showing resistance to small-molecule CCR5 antagonists

V3 loop sequences of recombinant viruses	TAK-779	MVC	VCV
	PMI (95% CI)	PMI (95% CI)	PMI (95% CI)
07J-W0 backbone
CTRPGNNTRKSTRIGPGQTFFATGDIIGDIRQAHC*	106.7 (96.8, 116.6)	101.1 (96.2, 106.0)	94.6 (86.8, 102.6)
S306P/T307I/F318I/T320R/G321E	83.0 (76.3, 89.7)	77.2 (73.7, 80.8)	−55.5 (−66.7, −44.4)
K305R/S306P/T307I/F318I/T320R/G321E	59.7 (52.2, 67.2)	49.7 (45.3, 54.0)	−133.5 (−150, −116.6)
K305R/S306P/T307I/F318I/T320R/G321E/H330Y	61.7 (55.4, 68.0)	51.7 (46.6, 56.7)	−106.2 (−119.7, −92.7)
K305R/S306P/T307I/F318I/T320R/G321E/S365V	68.4 (62.6, 74.1)	59.2 (55.1, 63.2)	−69.6 (−82.8, −56.5)
K305R/S306P/T307I/F318I/T320R/G321E/H330Y/S365V	49.1 (41.2, 57.0)	46.4 (42.7, 50.2)	−116.3 (−131.8, −100.8)
07J-W28 backbone
CTRPGNNTRRPIRIGPGQTFIAREDIIGDIRQAYC†	−10.3 (−3.5, 15.4)	13.4 (8.0, 18.9)	−9.9 (−19.0, −0.7)
305R→K	32.9 (21.4, 44.5)	42.0 (38.2, 45.8)	14.7 (9.5, 19.8)
306P→S	66.9 (60.2, 73.6)	75.9 (73.6, 78.2)	36.6 (30.9, 42.3)

Note: PMI = percent maximal inhibition, CI = confidence intervals. Data shown are means of at least two determinations.

^*Full-length 07J-W0 envelope; amino acid V3 sequence shown (starting at HXB2 position 296)

^†Full-length envelope from 017-W28; amino acid V3 sequence shown