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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Curr Opin Cell Biol. 2010 Dec 17;23(3):318–324. doi: 10.1016/j.ceb.2010.11.007

Figure 1.

Figure 1

Proximal variable regions in the immunoglobulin heavy chain locus are frequently associated with nearby CTCF occupancy. CTCF binding, determined by ChIP-sequencing is shown for Rag-1 deficient pro-B cells (42). CTCF occupancy is closely linked with the presence of proximal VH regions. Only few VH regions are highlighted but a similar pattern is observed for the entire proximal VH region cluster. Pseudo VH regions, on the other hand, are not located within close genomic proximity of the proximal VH regions.