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. Author manuscript; available in PMC: 2011 Apr 4.
Published in final edited form as: Cell Stem Cell. 2008 Feb 7;2(2):160–169. doi: 10.1016/j.stem.2007.12.011

Figure 7. A Schematic Summary of Epigenetic and Transcriptional Regulation in mESCs.

Figure 7

The patterns of DNA methylation and histone modifications are depicted into four subclasses of gene promoters with H3K4me3 (i), bivalent genes (ii) with (a.) or without (b.) polycomb binding, H3K27me3 only (iii), and no histone marks (iv). Gene promoters are further annotated as HCP, ICP, and LCP that corresponds to different density of CpG dinucleotides and DNA methylation. Open circles designate unmethylated CpG sites, filled circles represent methylated CpG sites and half filled circles represent promoters which can be found either methylated or unmethylated. Unmethylated CpG islands are enriched in HCP promoters with H3K4me only or bivalent H3K4/K27 marks. Methylated CpGs are enriched in LCP and ICP gene promoters without H3 K4 and K27 trimethylation or with K27me3 only. The preferential interaction of Polycomb proteins and Oct4/Nanog complex with different classes of gene promoter is also illustrated. Different classes of genes that are either expressed or repressed in mESCs are listed next to each type of promoters.